Analysis of Hydroquinone in Face Whitening Cream by UV-Vis Spectrophotometry and GC-MS Spectrometry

  • Karnelasatri Karnelasatri Study Program of DIII Pharmacy, Faculty of Health Sciences, Universitas Pelita Harapan, Tangerang, Indonesia
  • Candra Yulius Tahya Study Program of Chemistry Education, Faculty of Education, Universitas Pelita Harapan, Tangerang, Indonesia
  • Mahda Uli Adila Study Program of DIII Pharmacy, Faculty of Health Sciences, Universitas Pelita Harapan, Tangerang, Indonesia
  • Junius Hardy Study Program of Pharmacy, Faculty of Health Sciences, Universitas Pelita Harapan, Tangerang, Indonesia
  • Sri Wahyu Ningsih Munthe Study Program of DIII Pharmacy, Faculty of Health Sciences, Universitas Pelita Harapan, Tangerang, Indonesia
DOI: https://doi.org/10.30598/ijcr.2024.11-kar
Keywords: Whitening creams, Hydroquinone, Cerimetry, UV-Vis Spectrophotometry, Gas Chromatography-mass spectrometry (GC-MS)

Abstract

The analytical method to determine the compound content in both food and cosmetic products must be carried out carefully to ensure the validity of the analysis results. Hydroquinone has been widely found to be used as an active whitening agent in whitening cream. Technological advances have led to illegal whitening creams becoming more accessible online. This study aims to examine the hydroquinone content in the whitening samples cream purchased from e-commerce by various analytical methods, such as FeCl3 reagent, cerimetric titration, UV-Vis spectrophotometry, and GC-MS spectrometer compared to the positive control hydroquinone. The results of the hydroquinone content by cerimetric titration and UV-Vis spectrophotometry methods were calculated quantitatively. Furthermore, the result compared through statistical tests showed a consistent hydroquinone content for both methods. Contrariwise, the GC-MS method showed negative results due to differences in the extraction process and solvent solubility. Based on the result obtained, can be concluded that all samples of whitening cream did not meet the requirements of BPOM No. 23 of 2019. 

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Published
2024-01-15
How to Cite
(1)
Karnelasatri, K.; Tahya, C.; Adila, M.; Hardy, J.; Munthe, S. Analysis of Hydroquinone in Face Whitening Cream by UV-Vis Spectrophotometry and GC-MS Spectrometry. Indo. J. Chem. Res. 2024, 11, 205-211.
Issue
Vol 11 No 3 (2024): Edition for January 2024
Section
Research articles

Copyright (c) 2024 Karnelasatri Karnelasatri, Candra Yulius Tahya, Mahda Uli Adila, Junius Hardy, Sri Wahyu Ningsih Munthe

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