PERAN HORMON PERTUMBUHAN DALAM PERCEPATAN PROSES AGING
Keywords:
Growth hormone, aging, IGF-, mTOR
Abstract
Aging is a process that must be experienced by living things, including humans, which causes a decrease in bodily functions. Various theories of aging show the interference of the body's regulatory system from upstream to downstream. One of the regulations that influence is hormonal regulation which is played by growth hormone. Various literature studies show that growth hormone accelerates the aging process. The primary mechanism involves reducing the formation of endogenous antioxidants due to insulin-like growth factor I (IGF-1) activity and decreased metabolic activity regulated by mammalian target of rapamycin (mTOR).
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References
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2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461–4.
3. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277:942–7.
4. Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics. 1998;148:703–17.
5. Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000;408:255–62.
6. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182.
7. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. Dwarf mice and the aging process. Nature. 1996;384:33.
8. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A. Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci. 2003;58:291–6.
9. Lieberman M, Peet A. Marks’ basic medical biochemistry: a clinical approach. 5th.ed. Philadelphia. Wolters Kluwe. 2018. p. 1588-93.
10. Baynes JW, Dominiczak MH. Biokimia Kedokteran. Ed 5. Wanandi SI, Jusman SWA, editor. Elsevier Singapore Pte Ltd. 2021.
11. Bartke A. Sun LY, Longo V. Somatotropic signal: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013 Apr; 93(2): 571–98.
12. Wrigley S, Arafa D, Tropea D. Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. Front. Cell. Neurosci. 2017.
13. Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol Pathol. 2001;54(5): 311–6.
14. Westley RL, May FE. A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors. International Journal of Endocrinology. 2013.
15. Hakumo F, Takahashi SI. 40 years of IGF1: IGF1 receptor signaling pathways. J Mol Endocrinol. 2018;61(1):69-86.
16. Jin K. Modern biological theories of aging. Aging Dis. 2010;1(2):72–4.
17. Cabrera AJR. Theories of human aging of molecules to society. MOJ Immunol. 2015; 2(2):1-6.
18. Ziada AS, Smith MSR, Cote HCF. Updating the free radical theory of aging. Front Cell Dev Biol. 2020;8: 575-645.
19. Bartkle A, Darcy J. GH and ageing: pitfalls and new insights. Best Pract Res Clin Endocrinol Metab. 2017;31(1):113–25.
20. Bartkle A, List EO, Kopchick JJ. The somatotropic axis and aging: benefits of endocrine defects. Growth Horm IGF Res. 2016;27:41–5.
21. Bartake A. Minireview: Role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology. 2005;146(9):3718-23.
22. Fontana L, Partrige L, Longo VD. Dietary restriction, growth factor and aging : from yeast to human. Science. 2010; 328(5976):321–6.
23. Gong Y, Luo S, Zhu H, Li Yuling, Huang W. Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome. ReprodBiol Endocrinol. 2020;18:121.
24. Junnila RK, List EO, Berryman DE, Murrey JW, Kopchick. The GH/IGF axis in ageing and longevity. Nat Rev Endocrinol. 2013; 9(6):366–76.
25. Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Suda K, et al. Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans. Growth Horm. IGF Res. 2012; 22(2):54-68.
26. Keane J, Tajouri L, Gray B. Recombinant human growth hormone and insulin-like growth factor-1 do not affect mitochondrial derived highly reactive oxygen species production in peripheral blood mononuclear cells under conditions of substrate saturation in-vitro. Nutr Metab. 2016;13:45.
Published
2023-04-28
How to Cite
1.
Lima FV. PERAN HORMON PERTUMBUHAN DALAM PERCEPATAN PROSES AGING. PAMERI [Internet]. 28Apr.2023 [cited 6Nov.2024];5(1):23-0. Available from: https://ojs3.unpatti.ac.id/index.php/pameri/article/view/8752
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