Identification and Sensivity Test of Pseudomonas aeruginosa to Ciprofloxacin and Ceftazidime in Diabetic Ulcers

  • Safitri Nur Istiqomah Department of Medical Laboratory Technology, National College of Health Sciences, Sukoharjo, Indonesia
  • Didik Wahyudi Department of Medical Laboratory Technology, National College of Health Sciences, Sukoharjo, Indonesia
Keywords: Pseudomonas aeruginosa; Diabetic Ulcers; Antibiotic Sensivity; Ciprofloxacin; Ceftazidime

Abstract

Diabetic ulcers are a serious complication in diabetic patients, often becoming infected with various pathogenic bacteria, including Pseudomonas aeruginosa, which is known for its high resistance to multiple antibiotics. This study aimed to identify the presence of Pseudomonas aeruginosa in diabetic ulcers and evaluate its sensitivity to the antibiotics ciprofloxacin and ceftazidime at the Diabetic Wound Care Center (RUMAT) in Surakarta. The research used a descriptive observational design with the Kirby-Bauer disk diffusion method for antibiotic susceptibility testing, along with bacterial isolation, Gram staining, and biochemical tests for identification. The results showed that out of 8 specimens examined, 4 specimens (50%) were identified as Pseudomonas aeruginosa, all of which demonstrated sensitivity to ciprofloxacin and ceftazidime, with inhibition zones above the sensitive standard according to CLSI M100 2023.

Downloads

Download data is not yet available.

References

Amalia F.,F. (2020). Aktivitas Antibakteri Kopi Robusta Dalam mempercepat Kejadian Penyembuhan Luka pada Ulkus Diabetikum. Healthy Tadulako Journal.

Anggriawan, F., Endriani, R., & Sembiring, L. P. (2014). Identifikasi Bakteri Batang Gram Negatif Penghasil Extended Spectrum β Lactamase dari Ulkus Diabetikum Derajat I dan II Waigner di Bangsal Penyakit Dalam RSUD Arifin Acmad Provinsi Riau. Fakultas Kedokteran Universitas Riau Repository, 1.

Arisandi, D., Amaludin, M., Hatmalyakin, D., Alfikrie, F., Hidayat, U. R., Akbar, A., & Nurpratiwi, N. (2023). Kemandirian Masyarakat dalam Pencegahan dan Deteksi Dini Diabetic Foot Ulcer (DFU) pada Penderita Diabetes Melitus di Desa Pulau Lemukutan Kecamatan Sungai Raya Kepulauan Kabupaten Bengkayang Provinsi Kalimantan Barat. Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM), 6(7), 2869–2877. https://doi.org/10.33024/jkpm.v6i7.10091

Arivo, D., & Dwiningtyas, A. W. (2017). Uji Sensitivitas Antibiotik Terhadap Escherichia coli Penyebab Infeksi Saluran Kemih. Jurnal Ilmu Kedokteran Dan Kesehatan, 4(2)

Aryzki S., A. M. , R. S. (2020). Gambaran Penggunaan Antibiotik Pada Pasien Ulkus Diabetikum Di Instalasi Rawat Jalan Penyakit Dalam RSUD Ulih Banjarmasin Priode Juli - Desember 2018. Junrla Ilmiah Manuntung, 6.

Azahra F. (2021). Uji Sensitivitas Bakteri Patogen pada Ulkus Pasien Diabetes Mellitus Tipe-2.

Budiyanto, R., Satriawan, N. E., & Suryani, A. (2021). Identifikasi dan Uji Resistensi Staphylococcus aureus Terhadap Antibiotik (Chloramphenicol dan Cefotaxime Sodium) dari Pus Infeksi Piogenik di Puskesmas Proppo. Jurnal Kimia Riset, 6(2), 154–162.

Garousi, M., Monazamitabar, S., Mirazi, H., Farrokhi, Z., Khaledi, A., & Shakerimoghaddam, A. (2023). Review Epidemiology of Pseudomonas aeruginosa in diabetic foot infections: a global systematic review and meta-analysis. Www.Germs.Ro, 1. www.germs.ro

Gaur, P., Hada, V., Rath, R. S., Mohanty, A., Singh, P., & Rukadikar, A. (2023). Interpretation of Antimicrobial Susceptibility Testing Using European Committee on Antimicrobial Susceptibility Testing (EUCAST) and Clinical and Laboratory Standards Institute (CLSI) Breakpoints: Analysis of Agreement. Cureus. https://doi.org/10.7759/cureus.36977

Meilalita I., S. M. (2023). Gambaran Sensitivitas Antibiotik yang Diresepkam pada Pasein Ulkus Diabetikum di RSUD Kraton Kabupaten Pekalongan. Jurnal Anestesi: Jurnal Ilmu Kesehatan Dan Kedokteran, 1(2), 154–160. https://doi.org/10.59680/anestesi.v1i2.520

Mohamed, W. F., Askora, A. A., Mahdy, M. M. H., EL-Hussieny, E. A., & Abu-Shady, H. M. (2022). Isolation and Characterization of Bacteriophages Active against Pseudomonas aeruginosa Strains Isolated from Diabetic Foot Infections. Archives of Razi Institute,77(6),2187–2200. https://doi.org/10.22092/ARI.2022.359032.2357

Nagaya, R., R, P., Deva, R., Jagadeesh, Y., Emmanuel, P., & Narayan, G. (2024). Optimizing Antibiotic Treatment for Diabetic Foot Infections: A Study From a Tertiary Public Healthcare Center in Puducherry, South India. Cureus. https://doi.org/10.7759/cureus.60139

Novelni R, I. P. D. (2019). Identifikasi dan Uji Resistensi Bakteri pada Pasien Ulkus Diabetikum di Bangsal Interne RSUP Dr. M. Djamil Padang. Jurnal Penelitian Farmasi Indonesia, 8.

Kesuma, S., Wahyuni, D., & Azahra, S. (2021). Profil Bakteri Patogen dan Antibiotik pada Gangren Diabetes Melitus di RSUD Abdul Wahab Sjahranie Samarinda. Health Care : Jurnal Kesehatan, 12(1), 2023–2159. https://doi.org/10.36763/healthcare.v12i1.370

Rehman, A., Patrick, W. M., & Lamont, I. L. (2019). Mechanisms of ciprofloxacin resistance in pseudomonas aeruginosa: New approaches to an old problem. Journal of Medical Microbiology, 68(1), 1–10. https://doi.org/10.1099/jmm.0.000873

Rosyidah K.A., Z. A. , S. A. , M. N. , P. A. (2021). Analisis Faktor yang Berpengaruh dalam Pemgunaan AntibiotikSecara Bebas di Masyarakat Desa Pladen Kecamatan Jekulo, Kabupaten Kudus. The 13th University Research Colloqium, 1.

Septiana, P. A. V. , W. D. (2024). Identifikasi dan Uji Sensitivitas Staphylococcus Sp. Terhadap Beberapa Antibiotik Pada Ulkus Diabetikum. Media Kesehatan Politeknik Kesehatan Makassar, XIX(1). https://doi.org/10.32382/medkes.v19i1

Setianingsih, Y., Fadraersada, J., Ibrahim, A., Ramadhan, A. M., Samarinda, M., & Timur, K. (2016). Pola Resistensi Bakteri Terhadap Antibiotik Pada Pasien Diabetic Foot Di RSUD Abdul Wahab Sjahrania Samarinda Periode Agustus - Okteober 2016. Prosiding Seminar Nasional Kefarmasian Ke-4 (4).

Wahyudi, D., Aman, A. T., Handayani, N. S. N., & Soetarto, E. S. (2019). Differences among clinical isolates of Pseudomonas aeruginosa in their capability of forming biofilms and their susceptibility to antibiotics. Biodiversitas,. 20.(5), 1450–1456. https://doi.org/10.130_57/biodiv/d200538

Waworuntu P.J., (2016). Pola Bakteri Aerob pada pasien Ulkus Diabetikum di RSUP Prof. dr. R. D. Kandou Manado. Jurnal Kedokteran Klinik, 1.

Wijesinghe, G., Dilhari, A., Gayani, B., Kottegoda, N., Samaranayake, L., & Weerasekera, M. (2019). Influence of Laboratory Culture Media on in vitro Growth, Adhesion, and Biofilm Formation of Pseudomonas aeruginosa and Staphylococcus aureus. Medical Principles and Practice, 28(1), 28–35. https://doi.org/10.1159/000494757

Published
2025-10-31
How to Cite
Istiqomah, S. N., & Wahyudi, D. (2025). Identification and Sensivity Test of Pseudomonas aeruginosa to Ciprofloxacin and Ceftazidime in Diabetic Ulcers. BIOPENDIX: Jurnal Biologi, Pendidikan Dan Terapan, 12(2), 116-122. https://doi.org/10.30598/biopendixvol12issue2page116-122