SINTESIS DAN UJI AKTIVITAS ANTIMALARIA SENYAWA (1)-N-BENZIL-1,10- FENANTROLINIUM BROMIDA

  • Ruslin Hadanu Pattimura University Ambon
  • Sabirin Mastjeh Gadjah Mada University
  • Jumina Jumina Gadjah Mada University
  • Mustafa Mustafa Gadjah Mada University
  • Eti Nurwening Sholikhah Gadjah Mada University
  • Mahardika Agus Wijayanti Gadjah Mada University
Keywords: 1,10-phenanthroline, substitution, alkylation, antiplasmodial, antimalarial activity

Abstract

A synthetic methods was employed to prepare (1)-N-benzyl)-1,10-phenanthroliniumbromide 4 from 1,10phenanthroline 3 and benzylchloride 1 through substitution and alkylation reactions. The compound (1)-Nbenzyl)-1,10-phenanthroliniumbromide 4 was tested through antiplasmodial test. The benzylbromide 2 was synthesized through substitution reaction of benzylchloride 1 and NaBr which has a yield of 74.25%. The (1)-N-benzyl)-1,10-phenanthroliniumbromide 4 was synthesized from 1,10-phenanthroline 3 using benzylbromide 2 reagents which refluxed for 8 hours with 84.04% yields. The results of testing in in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum FCR3 strain to (1)-N-benzyl)-1,10-  phenanthroliniumbromide 4 has high antimalarial activity (IC50 : 0.10±0.04 µM)

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Published
2020-05-28
How to Cite
Hadanu, R., Mastjeh, S., Jumina, J., Mustafa, M., Sholikhah, E., & Wijayanti, M. (2020). SINTESIS DAN UJI AKTIVITAS ANTIMALARIA SENYAWA (1)-N-BENZIL-1,10- FENANTROLINIUM BROMIDA. Molluca Journal of Chemistry Education (MJoCE), 1(2), 92-102. https://doi.org/10.30598/MJoCEvol1iss2pp92-102