• Marissa Beatrix Kunu
  • Chomsa Dintasari Umi Baszary BIOLOGI-UNPATTI
  • Amos Killay
Keywords: diabetes mellitus, abnormalities sperm, strychnos lucida.


Diabetes mellitus, known as diabetes or blood sugar disease, is a group of chronic diseases characterized by increased blood sugar level (hyperglycemia). Prolonged hyperglycemia conditions will cause an increase in ROS (Reactive Oxygen Spesies) production by the mitochondria, which then cause damage to the mitochondrial membrane resulting in loss of function of the mitochondrial membrane potential and can induce sperm cells apoptosis. This study aims to determine effect of kayu ular (Strychnos lucida) steeping on decreasing spermatozoa abnormalities of mice (Mus musculus) diabetes mellitus model. The result showed that administration of kayu ular steeping at concentration of 2,6gr/50ml was signicantly reduced (P<0.05) spermatozoa abnormality. This dose is the most effective concentration to decreased the spermatozoa abnormality of mice. This though to be due to the active compounds found in steeping kayu ular (Strychnos lucida) which can counteract free radicals due to diabetes mellitus that decreasing spermatozoa abnormalities.


Download data is not yet available.


Indonesian Ministry of Health. 2015. Indonesian Basic Health Survey. Jakarta: Ministry of Health of the Republic of Indonesia. IDF (International Diabetes Federation). Diabetes Atlas. Revised 7th Edition.

Yang J, S., lin, G., Wu, M., Liu, X. Luan, Q., LV, He Z. , Jianmin. 2010. Preventive effect of taurine in experimental type II diabetic nephropathy. J of Biomed Sci 17(1)546.

Rachmadi A. 2008. Blood sugar levels and testosterone hormone levels in men with diabetes mellitus, their specifications for sexual dysfunction and the differences between those who do not experience sexual dysfunction. Thesis. Diponegoro University: 1-79.

Gusmalina K. and Sri. 2015. Exploration of the potential of snakewood (Strychons lucida) organic compounds as a biopharmaceutical source. Forest Products Research and Development Center, Forestry Research and Development Agency. Bogor. Volume 1, Number 7.

Lukacinova A., J, Mojzis, R. Benacka, J. Keller. T. Maguth, P. Kurila. L. vaxone. 2008. Preventive effect of flavonoids on alloxan-induced diabetes mellitus in rats. Acta Veterina, 77:175-82.

Dalimartha. 2007. Traditional herbs for the treatment of diabetes mellitus. Jakarta: Self-Help Spreader. matter. 59.

Fibullah R.M., Sutyarso, H. Busman, S. Rahmanisa. 2015. Curative effect of administering white dragon fruit (Hylocereus undatus) juice on the motility, number and morphology of male white rat (Rattus norvegicus) spermatozoa of the Sprague Dawley strain which induces cyproterone acetate. J. Agromedic Unila. 4(9).

Suparni. 2009. Effect of vitamin C administration on sperm count and sperm morphology of male mice (Mus musculus) exposed to Monosodium Glutamate (MSG). Thesis. Graduate School. University of Northern Sumatra. Medan.

Zhang, Shu-Yun., Ito, Yuki. 2007. Yamanoshita, Osamu Permethrin can interfere with testosterone biosynthesis through damage to the mitochondrial membrane of Leydig cells in adult male mice. J. Endocrine Social. 148:3941-394.

Faranita O. V. 2009. Quality of spermatozoa in male Wistar rats with diabetes mellitus. Final Research Report Scientific Writing. Semarang: Diponegoro University.

Zulfa. 2006. Making organoclay from dentonite and DI (hydrogenated tallow) dimetrimonium chloride for nanocomposite applications. Syarif Hidayatulah State Islamic University Jakarta.

Ascobat P. 2008. Androgens, antiandrogens and anabolic steroids In: Pharmacology and therapy of methanol extract of male papaya (Carica papaya) flowers against multi-antibiotic resistant Escherichia coli and Staphylococcus aureus. Faculty of Pharmacy. Muhammadiyah University of Surakarta, Surakarta.

D. F. Souhoka, M. J. Matatula., W. Marlene Messang-Nalley and M. Rizal. 2009. Lactose maintains the viability of Etawah crossbreed goat spermatozoa preserved with Priangan sheep semen plasma. Veterinary Journal. Volume 10 No.3: 135-142.

Retired. D. 2006. The effect of giving tomato juice (Lycopericum esculentum mill) on the number of spermatozoa in male balb/c mice exposed to cigarette smoke (Thesis). Medical School. Diponegoro University. Semarang.

I.N. Suartha. 2005. Jung Rahab (Baeckea frute-scens Linn.) leaf extract inhibits spermatogenesis in mice (Mus musculus). Master's Thesis. Graduate program. Reproductive Medicine Study Program. Udayana University.

Hariyatmi. 2004. The ability of vitamin E as an antioxidant against free radicals in old age. MIPA, 14(1), 52-60.

K. Sayuti, and R. Yenrina. 2015. Natural and synthetic antioxidants. Andalas University Press. Padang.

How to Cite
Kunu, Marissa, Chomsa Baszary, and Amos Killay. 2020. “ADMINISTRATED OF SNAKE WOOD (Strychnos Lucida) TO DECREASED ABNORMALITY SPERMATOZOA OF MICE (Mus Musculus) DIABETES MELLITUS MODELING”. RUMPHIUS Pattimura Biological Journal 2 (2), 037-042.