Effect of Soy Isoflavones on the Serum Lipid Profile and Vascular Function
Keywords:
soy, soy isoflavones, vascular function
Abstract
Soybeans are unique among the legumes because they are a concentrated source of isoflavones. A number of components of soy have been studied to investigate their potential effect on CVD. Soy proteins have been shown to lower LDL-cholesterol and to have neutral or slightly positive effect on HDL-cholesterol. However, to what extend actually is the role of the isoflavone in this action remained contradictive. This review describes the characteristics and the nature of the soy isoflavones as well as covering the results from several studies to determine the effect of soy isoflavones on the serum lipid and vascular functions.
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References
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Williams, J. K, & T. B. Clarckson. 1998. Dietary soy isoflavones inhibit invivo constrictor responses of coronary arteries to collagen-induced platelet activation. Coronary Artery Disease 9: 759-764.
Yamakoshi, J., M. K. Piskula, & T. Izumi. 2000. Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits. Journal of Nutrition 130: 1887-1893.
Anderson, J. W., B. M. Johnstone, & M. E. Cook-Newell. 1995. Meta-analysis of the effects of soy protein intake in serum lipids. The New England Journal of Medecine 333: 276-282.
Anthony, M. S., T. B. Clarckson., B.C. Bullock, & J. D. Wagner. 1997. Soy protein versus soy phytoestrogens in the prevention of diet induced coronary artery atherosclerosis of male cynomolgus monkeys. Arteriosclerosis, Thrombsis, and Vascular Biology 17: 2524-2531.
Anthony, M. S., T. B. Clarckson, & J. K. Williams. 1998. Effect of soy isoflavones on atherosclerosis: Potential mechanisms. The American Journal of Clinical Nutrition 68: 1390S-1393S.
Balmir, F., R. Staack., E. Jefferey., M. D. Berber Jimenez., L. Wang, & S. M. Potter. 1996. An extract of soy flour influences serum cholesterol and tyroid hormones in rats and hamster. Journal of Nutrition 126: 3046-3053.
Barnes, S., B. Boersma., R. Patel., M. Kirk., V. M. Darley-Usmar., H. Kim, & J. Xu. 2000. Isoflavonoids and chronic disease: Mechanism of action. BioFactors 12: 209-215.
Crouse, J. R., T. Morgan., J. G. Terry., J. Ellis., M. Vitolins, & G. L. Burke. 1999. A randomized trial comparing the effect of casein with that of soy protein containing varying amount of isoflavones on plasma concentrations of lipids and lipoprotein. Archive of Internal Medecine 159: 2070-2076.
FDA. 1999. Food labelling: Health claims: Soy protein and coronary heart disease. Federal register 64SR 57699 : 57621CFR Part 57101.
Greaves, K. A., J. S. Parks., J. K. Williams, & J. D. Wagner. 1999. Intact dietary soy protein, but not adding an isoflavone rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. Journal of Nutrition 129: 1585-1592.
Honore, E. K., J. K. Williams., M. S. Anthony, & T. B. Clarckson. 1997. Soy isoflavones enhance vascular reactivity in atherosclerosis female macaques. Fertility and Sterility 67: 148-154.
Knight, D. C., P. L. Wall, & J. A. Eden. 1996. A review of phytoestrogens and their effects in relation to menopausal symptoms. Australian Journal of Nutrition and Dietetics 53: 5-11.
Kudou, S., Y. Fleuri., D. Weiti., D. Magnotato., T. Uchida., K. Kitamura, & K. Okubo. 1991. Malonylisoflavone glycosides in soybean seeds. Agricultural and Biological Chemistry 55: 2227-2233.
Lampe, J. W. 2003. Isoflavonoid and lignin phytoestrogens as dietary biomarkers. Journal of Nutrition 133: 956S-964S.
Lichtenstein, A. H., S. M. Jalbert, & H. Adlercreutz. 2002. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arteriosclerosis, Thrombsis, and Vascular Biology 22: 1852-1858.
Lucas, E A., D. A. Khalil., B. P. Daggy, & B. H Arjmandi. 2001. Ethanol-extracted soy protein isolate does not modulate serum cholesterol in golden Syrian hamsters : A model of postmenopausal hypercholesterolemia. Journal of Nutrition 131: 211-214.
Messina, M. J. 1999. Legumes and soybeans : Overview of their nutritional profile and health effects. The American Journal of Clinical Nutrition 70: 439S-450S.
Nestel, P. J., T. Yamashita, & T. Sasahara. 1997. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arteriosclerosis, Thrombsis, and Vascular Biology 3392-3398.
Rowland, I., M. Faughman., L. Hoey., K. Wahala., G. Williamson, & A. Cassidy. 2003. Bioavailability of phytoestrogens. British Journal Of Nutrition 89: 45-58.
Squardito, F., D. Altavilla, & N. Morabito. 2002. The effect of phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 163: 339-347.
Steinberg, F. M., N. L. Guthrie., A. C. Villablanca., K. Kumar, & M.J Murray. 2003. Soy protein with isoflavones has favourable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. The American Journal of Clinical Nutrition 78: 123-130.
Uesugi, T., Y. Fukui, & Y. Yamori. 2002. Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipid in postmenopausal Japanese women. Journal of American College of Nutrition 21: 97-102.
Wagner, J. D., M. S. Anthony., K. N. Litwak., L. Zhang, & T. B. Clarckson. 1997. Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized cynamolgus monkeys. Metabolism 46: 668-705.
Weggemans, R. M, & E. A. Trautwein. 2003. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in human: A meta-analysis. European Journal of Clinical Nutrition 57: 940-946.
Williams, J. K, & T. B. Clarckson. 1998. Dietary soy isoflavones inhibit invivo constrictor responses of coronary arteries to collagen-induced platelet activation. Coronary Artery Disease 9: 759-764.
Yamakoshi, J., M. K. Piskula, & T. Izumi. 2000. Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits. Journal of Nutrition 130: 1887-1893.
Published
2015-04-01
How to Cite
Tuhumury, H. (2015). Effect of Soy Isoflavones on the Serum Lipid Profile and Vascular Function. AGRITEKNO: Jurnal Teknologi Pertanian, 4(1), 1-7. Retrieved from https://ojs3.unpatti.ac.id/index.php/agritekno/article/view/32
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Review Articles
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