Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina dari Asam Ferulat Melalui Metode Konversi Tidak Langsung

Synthesis of Amide Derivative N-4-O-Asetilferuloylmorpholine From Ferulic Acid Via Indirect Conversion Method

  • Sabir Sumarna Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
  • Firdaus Firdaus Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
  • Nunuk H. Soekamto Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
DOI: https://doi.org/10.30598/ijcr.2016.4-sab
Keywords: N-4-O-asetilferuloylmorpholine, ferulic acid, acetylation, chlorination, amidation

Abstract

Synthesis of N-4-O-asetilferuloylmorpholine from ferulic acid via indirect conversion methods with acetylation, chlorination and amidation (in situ) reactions have been conducted. The acetylation was carried out using acetic anhydride reagent in pyridine solvent at room temperature for 6 hours. The chlorination was performed with thionyl chloride in benzene solvent by reflux at 75°C for 4 hours, proceeded by in situ amidation utilizing morpholine in the presence of triethylamine and pyridine using dichloromethane solvent at room temperature. The target molecule as white crystalline solids with m.p. of 91-92°C. Characterization of these compounds was committed by FTIR spectrophotometry.

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Published
2016-01-31
How to Cite
(1)
Sumarna, S.; Firdaus, F.; Soekamto, N. Sintesis Turunan Amida N-4-O-Asetilferuloilmorfolina Dari Asam Ferulat Melalui Metode Konversi Tidak Langsung. Indo. J. Chem. Res. 2016, 4, 331-334.
Issue
Vol 4 No 1 (2016): Edisi Bulan Juli (Edition For July)
Section
Short communication

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