Sintesis Senyawa N-fenetil 4-O-asetil ferulamida dari Asam Ferulat melalui Reaksi Amidasi Tidak Langsung

Synthesis of Compound N-Phenetyl 4-O-Acetyl Ferulamide From Ferulic Acid Through Indirect Amidation Method

  • Muhammad Fajar Islam Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
  • Firdaus Firdaus Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
  • Nunuk H. Soekamto Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hassanuddin-Indonesia
DOI: https://doi.org/10.30598/ijcr.2016.4-muh
Keywords: N-phenetyl 4-O-acetyl ferulamide, ferulic acid, indirect amidation

Abstract

Compound N-phenetyl 4-O-asetil ferulamide had been synthesized from ferulic acid and phenetylamine through esterification and indirect amidation method. Esterification reaction of ferulic acid with anhydride acetate was done in pyridine solvent at room temperature. Indirect amidation was perform by chlorination using tionyl chloride in benzene solvent at 70°C and continued by amidation with phenetylamine, catalyzed by pyridine in dichloromethane solvent at room temperature. the compound obtained is brown yellowish crystal with melting point 118-120°C. The rendemen of target compound is 53.81%.

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Published
2016-01-31
How to Cite
(1)
Islam, M.; Firdaus, F.; Soekamto, N. Sintesis Senyawa N-Fenetil 4-O-Asetil Ferulamida Dari Asam Ferulat Melalui Reaksi Amidasi Tidak Langsung. Indo. J. Chem. Res. 2016, 4, 344-347.
Issue
Vol 4 No 1 (2016): Edisi Bulan Juli (Edition For July)
Section
Short communication

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