EFFECTIVENESS OF ETHANOL EXTRACT MEAT FRUIT MAHKOTA DEWA (Phaleria macrocarpa (Scheff) Boerl) ON REDUCE URIC ACID LEVELS IN MALE MICE (Mus musculus)
Abstract
Mahkota Dewa (Phaleria macrocarpa (Sceff.) Boerl.) is a medicinal plant that is used empirically as a medicine for various diseases, one of which is gout. This study aims to determine the ethanol extract of the crown of the gods in reducing uric acid levels in mice. This study used an experimental method with the research subject being male mice (mus musculus) and the object of research was the decrease in uric acid levels in mice when given treatment. The independent variable was the ethanol extract of the crown of the god flesh and the dependent variable was uric acid levels in male mice (Mus musculus). Data on the percentage decrease in uric acid levels was tested using one-way ANOVA (5% confidence level) followed by the Bonferroni test. The results showed that the dosage of ethanol extract of Mahkota Dewa fruit was 1.25; 2,5 and 5g/kgbw were able to reduce uric acid levels in the blood serum of male mice induced by potassium oxonate. of the five treatment groups, the average uric acid level with the negative control was 0.48 ± 0.04 mg/dl. Positive control was 0.62 ± 0.08 mg/dl. The ethanol extract dose of 1.25g/kgBB was 1.68 ± 0.13. The ethanol extract dose of 2.5g/kgbw was 1.62 ± 0.08 and the ethanol extract dose of 5g/kgBW was 1 ± 0.5.
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References
Arini, S. 2003. Antioxidant Power and Flavonoid Content from Ethanol-Water Extraction of Mahkota Dewa Fruit Flesh (Phaleria macrocarpa (Scheff.) Boerl), Journal, Faculty of Pharmacy, Gadjah Mada University, Jogjakarta.
Cos, P., Ying, L., Calomme, M., Hu, J.P., Cimanga, K., Poel V.B., Pieters, L., Vlietinck, A.J and Berghe, D.V. 1998. Structure-Activity Relationship and Clacification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers, Journal of Natural Products. 61 (2) 71-76.
Gotama, I.B. 1999. Inventory of Medicinal Plants (V), Ministry of Health, Health Research & Development Agency: Jakarta.
Habsari, N. R. E. 2010. Effect of Hexane Extract from the Flesh of Mahkota Dewa Fruit (Phaleria macrocrpa (Scheff.) Boerl) on Reducing Uric Acid Levels of Male White Mice Induced by Potassium Oxonate, Thesis, Faculty of Pharmacy, Muhammadiyah University of Surakarta, Surakarta.
Haidari, Fatemeh., Rashidi, M.R., Keshavarz, Seid., Mahboob, S.A., Eshraghian, M.R and Shahi, M.M. 2008. Effect of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats, Journal of Biological Sciences, Tehran University of Medical Sciences, Iran.
Harmanto, N. 2001. Crown of the Medicine God, Heirloom of the Gods, Agromedia Pustaka, Jakarta.
Hendra, P. 2005. Subchronic Toxicity of Fresh Juice of Mahkota Dewa (Phaleria macrocrpa (Scheff.) Boerl) on the Kidney Function of Male and Female Rats, Research Journal, Faculty of Pharmacy, Sanata Dharma University, Jogjakarta.
Kumia, A, Pertamawati, Rifatul and Hendig. 2005. Effects of Invitro THP-1 Cell-Line Growth Enhancer from Ethanol Extra of Mahkota Dewa Fruit (Phaleria macrocrpa (Scheff.). Artocarpus Journal. 5 (2) 89 -94.
Markham, K.R. 1988. How to Identify Flavonoids, translated by Padmawinata K., ITB Publisher, Bandung
Mo, Shi-Fhu., Zhou, Feng., Lv, Yao-Zhong, Hu, Qing-Hua., Zhang, Dong-Mei., and kong Ling-Dong. 2007. Hypouricemic Action of Selected Flavonoits in Mice : Structure -Activity Relationship, Nanjing University, China.
Prisma, E. 2002. Hypoglycemic Effect of Infusion of Simplicia Flesh of Mahkota Dewa Fruit (Phaleria macrocrpa (Scheff.) on White Male Rats, Thesis, Faculty of Pharmacy, Gadjamada University, Jogjakarta.
Setiani, L. A. 2010. Effect of Simplicia Infusion of Mahkota Dewa Fruit Flesh (Phaleria macrocrpa (Scheff.) Boerl) on reducing blood uric acid levels of male white mice induced by potassium oxonate, Thesis, Faculty of Surakarta Muhammadiyah University, Surakarta.
Simon, H., Etikun, M.J, Godine J.E., Hellen, D., Kutter, I., Shellito, and P.C., Stern, T.A. 2001. Gout Information Service Inc, New York. (http://www.nelcon rected.com).
Siswanto, A., and Nunuk Aries Nurulita. 2005. Anti-inflammatory Power of Infusion of Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl) Leaves on Male White Rats (Rattus norvegicus), Pharmacon, Faculty of Pharmacy, Muhammadiyah University Purwokerto, Jogjakarta.
Siswono. 2001. Crown of the Efficacious "Poison" God of Irian (Online), (gizinet.com) accessed 4 October.
Sudewo, B. 2004. Popular Medicinal Plants that Fight Various Diseases, Agromedia Pustaka, Jakarta.
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